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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

protein tyrosine kinase

" in MCE Product Catalog:

By Targets:	FLT3 (3) Antibiotic (1) Apoptosis (7) Autophagy (4) Bcr-Abl (5) c-Kit (5) c-Met/HGFR (7) c-Myc (1) CaMK (2) COX (1) Cyclic GMP-AMP Synthase (1) Discoidin Domain Receptor (1) Drug Metabolite (1) EGFR (11) ERK (1) FGFR (2) HIV (1) Insulin Receptor (2) Isotope-Labeled Compounds (1) JAK (5) p38 MAPK (1) PDGFR (7) Phosphatase (1) Phosphodiesterase (PDE) (1) Phospholipase (1) PKA (3) PKC (2) PROTACs (1) RAD51 (2) Ras (1) RET (3) Reverse Transcriptase (1) SARS-CoV (2) Src (9) STAT (1) TGF-β Receptor (1) Topoisomerase (1) Trk Receptor (2) Tyrosinase (1) VEGFR (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (30) Cardiovascular Disease (4) Endocrinology (1) Infection (2) Inflammation/Immunology (10) Metabolic Disease (5) Neurological Disease (1)

By Targets:

FLT3 (3)

Antibiotic (1)

Apoptosis (7)

Autophagy (4)

Bcr-Abl (5)

c-Kit (5)

c-Met/HGFR (7)

c-Myc (1)

CaMK (2)

COX (1)

Cyclic GMP-AMP Synthase (1)

Discoidin Domain Receptor (1)

Drug Metabolite (1)

EGFR (11)

ERK (1)

FGFR (2)

HIV (1)

Insulin Receptor (2)

Isotope-Labeled Compounds (1)

JAK (5)

p38 MAPK (1)

PDGFR (7)

Phosphatase (1)

Phosphodiesterase (PDE) (1)

Phospholipase (1)

PKA (3)

PKC (2)

PROTACs (1)

RAD51 (2)

Ras (1)

RET (3)

Reverse Transcriptase (1)

SARS-CoV (2)

Src (9)

STAT (1)

TGF-β Receptor (1)

Topoisomerase (1)

Trk Receptor (2)

Tyrosinase (1)

VEGFR (2)

Xanthine Oxidase (1)

By Research Areas:

Cancer (30)

Cardiovascular Disease (4)

Endocrinology (1)

Infection (2)

Inflammation/Immunology (10)

Metabolic Disease (5)

Neurological Disease (1)

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Targets Recommended: Btk Syk DYRK Pyk2 BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-P2503

*EGFR Protein* Tyrosine Kinase Substrate**	EGFR	Cancer
EGFR Protein Tyrosine Kinase Substrate 是EGFR 酪氨酸激酶的底物。

HY-N7160

2-Hydroxy-3-methylanthraquinone	Src Apoptosis	Cancer
大黄素杂质16 2-Hydroxy-3-methylanthraquinone (compound 1) 从白花蛇耳草的水提取物中分离得到。2-Hydroxy-3-methylanthraquinone 对蛋白酪氨酸激酶 (protein tyrosine kinases) v-src 和 pp60src有抑制作用，诱导 HepG2 癌细胞和凋亡 (apoptosis)。

HY-152830A

Adrixetinib TFA	Others	Cancer
Adrixetinib (TFA) 是一种蛋白酪氨酸激酶抑制剂，具有抗肿瘤活性。

HY-P1590

Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)	JAK	Inflammation/Immunology Cancer
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) 是小鼠JAK2 对应的475到491氨基酸序列的多肽。

HY-P0200

RR-SRC	Src	Inflammation/Immunology
RR-SRC 是 src-酪氨酸特异性蛋白激酶 (src-tyrosine-specific protein kinase) 的底物。

HY-163278

Lck-IN-2	Src Apoptosis	Cancer
Lck-IN-2 (compound 12a) 淋巴细胞特异性蛋白酪氨酸激酶 (Lck) 抑制剂，IC₅₀ 是 10.6 nM。Lck-IN-2 对结肠癌细胞具有活性，GI₅₀ 值为 0.24-1.26 μM。Lck-IN-2 在 Colo201 细胞中发挥凋亡 (apoptosis) 作用。

HY-160065

sgc8c aptamer sodium	Others	Cancer
sgc8c aptamer sodium 是特异性靶向人蛋白酪氨酸激酶 PTK-7 的适配体，PTK-7 主要在宫颈癌 Hela 细胞上表达。sgc8c aptamer sodium 与 PTK-7 的结合诱导了纳米标签在细胞表面的组装，从而产生强烈的荧光和 SERS 信号。对宫颈癌细胞具有特异性。

HY-121828

TX-1123	Src CaMK PKA EGFR PKC COX	Cancer
TX-1123 是一种有效的蛋白酪氨酸激酶 (PTK) 抑制剂，针对于 Src、eEF2-K、PKA 和 EGFR-K/PKC。TX-1123 是一种环氧合酶 (COX) 抑制剂，对 COX2 和 COX1 的 IC₅₀ 值分别为 1.16 μM 和 15.7 μM。TX-1123 具有低线粒体毒性。TX-1123 可用于癌症研究。

HY-P1785

Abl Cytosolic Substrate Abltide	Bcr-Abl	Cancer
Abl Cytosolic Substrate是Abl 酪氨酸激酶的底物。Abl 蛋白酪氨酸激酶是v-AbI蛋白酪氨酸激酶的一种截断形式，是Abelson小鼠白血病病毒Gag-Abl融合蛋白的一个伙伴。

HY-147612

Tyrosine kinase-IN-4	c-Met/HGFR	Cancer
Tyrosine kinase-IN-4 (EXAMPLE 107) 是一种酪氨酸激酶 (**tyrosine kinase**) 抑制剂。

HY-101962

HNMPA	Insulin Receptor	Metabolic Disease
HNMPA 是一种膜不可渗透的胰岛素受体酪氨酸激酶 (insulin receptor tyrosine kinase) 抑制剂。HNMPA 抑制人胰岛素受体的丝氨酸和酪氨酸自磷酸化。HNMPA 对蛋白激酶 C 或环 AMP 依赖性蛋白激酶活性没有影响。

HY-18316

RO495	JAK	Inflammation/Immunology
RO495 是一种非受体酪氨酸蛋白激酶2 (TYK2 kinase) 的有效抑制剂。

HY-152830

Adrixetinib	c-Met/HGFR	Cancer
Adrixetinib 是一种蛋白酪氨酸激酶抑制剂，具有抗肿瘤活性。

HY-148794

Risvodetinib IkT-148009	c-Met/HGFR	Cancer
Risvodetinib 是一种有效的蛋白酪氨酸激酶抑制剂。Risvodetinib 参与 Abelson 蛋白激酶 (c-Abl1、c-Abl2 和 c-kit) 抑制剂的合成。

HY-N2506

Ginsenoside Ra1	Others	Cardiovascular Disease
人参皂苷 Ra1 Ginsenoside Ra1 是人参中的成分，抑制缺氧/复氧诱导的蛋白酪氨酸激酶 (PTK) 的激活。

HY-133083

BAY-474	c-Met/HGFR	Cancer
BAY-474 是一种酪氨酸蛋白激酶 c-MET 抑制剂。BAY-474 可用作表观遗传学探针。

HY-125350

Entacapone acid Tyrphostin AG1290	c-Met/HGFR	Metabolic Disease
恩他卡朋EP杂质F；恩他卡朋欧洲药典杂质F Entacapone acid (Tyrphostin AG1290) 是一种酪氨酸激酶 (**tyrosine kinase**) 抑制剂。Entacapone acid 降低体内肝蛋白合成速率 (HPS)。

HY-138202

Lck-IN-1	Src	Inflammation/Immunology
Lck-IN-1 是一种有效的淋巴细胞蛋白酪氨酸激酶 (Lck) 抑制剂，详情请参考专利 WO2007013673A1, example 48。

HY-160144S

Lomedeucitinib BMS-986322	Isotope-Labeled Compounds	Inflammation/Immunology
Lomedeucitinib (BMS-986322) 通过靶向受体酪氨酸蛋白激酶 (TYK2) 发挥作用。Lomedeucitinib 可用于斑块状银屑病的研究。

HY-18926

VEGFR2-IN-7	VEGFR	Cancer
VEGFR2-IN-7 (compound E) 是 VEGFR2 的抑制剂。VEGFR2-IN-7 可用于癌症研究。

HY-W174279

Tyrphostin 8	EGFR Ras Phosphatase	Metabolic Disease
Tyrphostin 8 是一种酪氨酸激酶，抑制 EGFR 激酶的 IC₅₀ 值为 560 μM。Tyrphostin 8 也是一种 GTPase 抑制剂。Tyrphostin 8 可以抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC₅₀=21 μM)。

HY-N6732

K-252a 10 篇以上引用文献 SF2370; Antibiotic K 252a; Antibiotic SF 2370	PKC PKA CaMK Trk Receptor Autophagy Antibiotic	Infection Inflammation/Immunology
K-252a 是一种十字孢碱类似物，是蛋白激酶的抑制剂，对 PKC、PKA、II型钙调素依赖性激酶和磷酸化酶激酶的 IC₅₀ 值分别为470 nM、140 nM、270 nM和1.7 nM。K-252a 是一种有效抑制 NGF 受体 gp140trk 的酪氨酸蛋白激酶 (TRK) 活性，IC₅₀ 为 3 nM。

HY-137677B

GTPγS tetralithium	Others	Others
GTPγS (tetralithium) 是一种 G 蛋白激活剂，可保护蛋白质免遭蛋白水解降解，以酪氨酸激酶依赖性方式刺激 GLUT4 易位，刺激磷脂酶并诱导肌动蛋白聚合。GTPγS (tetralithium) 和 G 蛋白 α 联合可以用来研究激酶活力。GTPγS (tetralithium) 可以作为裂解缓冲液的组成成分。

HY-160689

GW694590A UNC10112731	c-Myc c-Kit Discoidin Domain Receptor PDGFR	Others
GW694590A (UNC10112731) 是 MYC 蛋白稳定剂，能够增加内源性 MYC 蛋白的水平。GW694590A 还靶向受体酪氨酸激酶，在 1 μM 时，对 DDR2、KIT 和 PDGFRα 的抑制率分别为 81%、68% 和 67%。GW694590A 是跨 ATP 依赖性和非依赖性荧光素酶的蛋白激酶抑制剂，对 Fluc 报告基因有潜在影响。

HY-18963

Lavendustin A RG-14355	EGFR	Cancer
薰草菌素 Lavendustin A (RG-14355) 是一种有效，选择性和 ATP 竞争性的表皮生长因子受体 (EGFR) 酪氨酸激酶抑制剂，IC₅₀ 值为 11 nM。Lavendustin A 不会抑制蛋白激酶 A 和 C。Lavendustin A 可以抑制 VEGF 诱导的血管生成。

HY-101246

RPI-1	RET	Cancer
RPI-1 是一种特异的口服 2-吲哚啉酮 Ret 酪氨酸激酶抑制剂。RPI-1 抑制人甲状腺髓样癌 TT 细胞增殖、Ret 酪氨酸磷酸化、Ret 蛋白表达及 PLCgamma、ERKs 和 AKT 的活化。具有抗肿瘤活性。

HY-103097

ST271	Phospholipase	Others
ST271 是一种蛋白质酪氨酸激酶 (PTK) 抑制剂，能够抑制 fMet-Leu-Phe 和 PAF 引起的 phospholipase D 活化，IC₅₀ 值分别为 6.7 和 9 μM。

HY-14435

Pyridone 6 5 篇以上引用文献	JAK	Cancer
吡啶酮6 Pyridone 6 是一种 pan-JAK 抑制剂，有效抑制 JAK 激酶家族，作用于 JAK2，TYK2，JAK3 和 JAK1，IC₅₀ 分别为 1 nM，1 nM，5 nM 和 15 nM。

HY-101959

Tyrphostin AG213 AG213	EGFR Topoisomerase	Cancer
Tyrphostin AG213 (AG213) 是一种表皮生长因子受体 (EGFR) 蛋白酪氨酸激酶抑制剂 (IC₅₀=0.85 μM)。Tyrphostin AG213 抑制酪氨酸激酶活性 (IC₅₀=2.4 μM) 和拓扑异构酶 II (IC₁₀₀=50 μM)。Tyrphostin AG213 还能够诱导肿瘤细胞发生非凋亡类型的细胞编程性死亡。

HY-101837

CGP 53716	Others	Inflammation/Immunology
CGP 53716是一种强效蛋白酪氨酸激酶抑制剂。CGP 53716具有血小板衍生生长因子(PDGF)受体的选择性活性。CGP 53716可用于由PDGF受体激活诱导的异常细胞增殖疾病的研究。

HY-136179

ZAP-180013 1 篇文献验证	Tyrosinase	Inflammation/Immunology
ZAP-180013 是一种 ZAP-70 抑制剂，IC₅₀ 为 1.8 μM。ZAP-180013 抑制 ZAP-70 SH2 结构域与基于免疫受体酪氨酸的激活基序 (ITAM) 的相互作用。

HY-125834

GMB-475	PROTACs Bcr-Abl Apoptosis	Cancer
GMB-475 是一个变构 BCR-ABL1 蛋白水解靶向嵌合体 (PROTAC)，靶向 BCR-ABL1 蛋白并募集 E3 连接酶 Von Hippel Lindau (VHL)，导致泛素化和随后的致癌融合蛋白降解。

HY-118203

SU4984	FGFR PDGFR Insulin Receptor	Cancer
SU4984 是一种蛋白质酪氨酸激酶抑制剂，抑制成纤维细胞生长因子受体 1 (FGFR1) 的 IC₅₀ 值为 10-20 μM。SU4984 还可抑制血小板衍生的生长因子受体和胰岛素受体的活性。SU4984 可用于癌症研究。

HY-N10411

Morin 3-O-β-D-glucopyranoside	Reverse Transcriptase HIV Xanthine Oxidase	Infection Cardiovascular Disease Cancer
Morin 3-O-β-D-glucopyranoside 是一种天然类黄酮，具有抗真菌、抗癌和抗氧化活性。Morin 3-O-β-D-glucopyranoside 抑制逆转录酶、蛋白酪氨酸激酶和黄嘌呤氧化酶，还具有抗 HIV、抗动脉硬化和超氧化物清除活性。

HY-15463

Imatinib 最多引用文献 70 篇文献验证 STI571; CGP-57148B	Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy	Cancer
伊马替尼 Imatinib (STI571) 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。Imatinib (STI571) 靠近 ATP 结合位点结合，将其锁定在封闭或自我抑制的构象中，因此半竞争性抑制蛋白质的酶活性。Imatinib 还抑制 SARS-CoV 和 MERS-CoV。

HY-15463S2

Imatinib-d3 hydrochloride STI571-d₃ hydrochloride; CGP-57148B-d₃ hydrochloride	Autophagy Bcr-Abl c-Kit SARS-CoV PDGFR	Cancer
伊马替尼 d₃ (盐酸盐) Imatinib-d₃ (hydrochloride) 是 Imatinib 的氘代物。Imatinib (STI571) 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。Imatinib (STI571) 靠近 ATP 结合位点结合，将其锁定在封闭或自我抑制的构象中，因此半竞争性抑制蛋白质的酶活性。Imatinib 还抑制 SARS-CoV 和 MERS-CoV。

HY-131275

Imatinib Impurity E	Drug Metabolite	Others
Imatinib Impurity E 是 Imatinib 的杂质。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。Imatinib (STI571) 靠近 ATP 结合位点结合，将其锁定在封闭或自我抑制的构象中，因此半竞争性抑制蛋白质的酶活性。Imatinib 还抑制 SARS-CoV 和 MERS-CoV。

HY-101960A

Tyrphostin A51 AG-183	EGFR	Others
Tyrphostin A51 是一种有效的蛋白酪氨酸激酶 (PTK) 抑制剂。Tyrphostin A51 以剂量依赖性方式抑制 [³H]牛磺酸的体积依赖性释放。Tyrphostin A51 显着降低细胞酪氨酰磷酸化水平。Tyrphostin A51 抑制基础和 EGF 诱导的人骨细胞增殖。

HY-123468

HA-1004	Cyclic GMP-AMP Synthase PKA ERK	Cardiovascular Disease Metabolic Disease
HA-1004 是一种 PKA 的选择性抑制剂，能抑制脂肪分解，诱导血管松弛。HA-1004 也是环 GMP 依赖性蛋白激酶和环 AMP 依赖性蛋白的双重抑制剂，参与着平滑肌、第二信使、环 AMP 和环 GMP 调节机制。HA-1004 可作为血管扩张剂抑制兔主动脉条收缩，或拮抗吗啡戒断大鼠模型中的 ERK 和酪氨酸羟化酶 (TH) 磷酸化。

HY-10206

Amuvatinib 5 篇以上引用文献 MP470; HPK 56	c-Kit PDGFR RAD51 FLT3 c-Met/HGFR RET Apoptosis	Cancer
Amuvatinib (MP470) 是一种多靶点酪氨酸激酶抑制剂，对突变 c-Kit，PDGFRα，Flt3，c-Met 和 c-Ret 具有有效活性。Amuvatinib (MP470) 还是一种 DNA 修复抑制剂，靶向蛋白 DNA 修复 RAD51，从而破坏 DNA 损伤修复。具有抗肿瘤活性。

HY-50868

Bafetinib 5 篇以上引用文献 INNO-406; NS-187	Bcr-Abl Src Apoptosis	Cancer
巴氟替尼 Bafetinib 是一种具有口服活性的 Lyn/Bcr-Abl 酪氨酸激酶抑制剂。Bafetinib 通过 Bcl-2 家族调节的内在凋亡途径增强几种促凋亡的 Bcl-2 同源性 (BH) 3-纯蛋白 (Bim、Bad、Bmf 和 Bik) 的活性，并诱导 Ph⁺ 白血病细胞凋亡。Bafetinib 具有抗肿瘤活性。

HY-10206A

Amuvatinib hydrochloride MP470 hydrochloride; HPK 56 hydrochloride	c-Kit PDGFR RAD51 FLT3 c-Met/HGFR RET	Cancer
Amuvatinib hydrochloride (MP470 hydrochloride) 是一种多靶点酪氨酸激酶抑制剂，对突变 c-Kit，PDGFRα，Flt3，c-Met 和 c-Ret 具有有效活性。Amuvatinib hydrochloride (MP470 hydrochloride) 还是一种 DNA 修复抑制剂，靶向蛋白 DNA 修复 RAD51，从而破坏 DNA 损伤修复。具有抗肿瘤活性。

HY-100499

Tyrphostin AG 528 Tyrphostin B66; AG 528	EGFR	Cancer
Tyrphostin AG-528 (Tyrphostin B66) 是一种蛋白酪氨酸激酶抑制剂，对表皮生长因子受体 (EGFR) 的 IC₅₀ 为 4.9 μM，对 ErbB2 的 IC₅₀ 为 2.1 μM。Tyrphostin AG-528 也是一种抗癌剂。

HY-18303

AMG-47a 2 篇文献验证	Src VEGFR p38 MAPK JAK	Inflammation/Immunology
AMG-47a 是一种有效的，具有口服活性的 Lck 抑制剂，其 IC₅₀ 值为 0.2 nM。AMG-47a 对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2 具有抑制作用，IC₅₀ 值分别为 1 nM、3 nM、72 nM、30 nM 和 21 nM。AMG-47a 具有抗炎作用。

HY-N4201

β-Hydroxyisovalerylshikonin	EGFR Src	Cancer
β-羟基异戊酰基紫草素 Beta-hydroxyisovalerylshikonin 是一种从Lithospermum erythrorhizon 中分离出的天然产物，是一种有效的 PTK 抑制剂，对 EGFR 和 v-Src 受体作用的 IC₅₀ 分别为 0.7 μM 和 1 μM。Beta-hydroxyisovalerylshikonin 对多种肿瘤细胞系均有抑制作用，能高效诱导 NCI-H522 和 DMS114 细胞的死亡。

HY-16558

Butein 3 篇文献验证 2’,3,4,4’-tetrahydroxy Chalcone	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)	Cancer
紫铆因 Butein 是一种 cAMP 特异性的 PDE 抑制剂，对 PDE4 的 IC₅₀为 10.4 μM。Butein 是蛋白酪氨酸激酶抑制剂，对 EGFR 和 p60^c-src 的 IC₅₀ 分别为 16 和 65 μM。Butein 通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。Butein 还是一种 SIRT1 激活剂 (STAC)。

HY-50867

Lestaurtinib 2 篇文献验证 CEP-701; KT-5555	JAK FLT3 Trk Receptor Apoptosis STAT	Cancer
来他替尼 Lestaurtinib 是一种口服有效的选择性受体酪氨酸激酶抑制剂，能竞争性地抑制 ATP 与 TrkA/B/C 激酶结合。Lestaurtinib 可抑制 RPTKs 的磷酸化，其对 FLT3、TrkA、JAK2 的 IC₅₀ 值分别为 2, 25 和 0.9 nM。Lestaurtinib 能诱导细胞凋亡和周期停滞，可显著抑制肿瘤的生长。

HY-101960

(Z)-Tyrphostin A51 (Z)-AG-183	EGFR	Others
(Z)-Tyrphostin A51 是 Lanoconazole A51 的 Z 构型形式。Tyrphostin A51 是一种有效的蛋白酪氨酸激酶 (PTK) 抑制剂。Tyrphostin A51 以剂量依赖性方式抑制 [³H]牛磺酸的体积依赖性释放。Tyrphostin A51 显着降低细胞酪氨酰磷酸化水平。Tyrphostin A51 抑制基础和 EGF 诱导的人骨细胞增殖。

HY-100434

PD-161570	FGFR PDGFR EGFR Src TGF-β Receptor	Cardiovascular Disease Cancer
PD-161570 是一种有效的且具有 ATP 竞争能力的人 FGF-1 受体抑制剂，IC₅₀ 为 39.9 nM，K_i 为 42 nM。PD-161570 还抑制 PDGFR，EGFR 和 c-Src 酪氨酸激酶，IC₅₀ 值分别为 310 nM，240 nM 和 44 nM。PD-161570 抑制 PDGF 刺激的自磷酸化和 FGF-1 受体磷酸化，IC₅₀ 分别为 450 nM 和 622 nM。PD-161570 还是一种骨形态发生蛋白 (BMPs) 和 TGF-β 信号抑制剂。

Cat. No.	Product Name

HY-L016

蛋白酪氨酸激酶化合物库

1055 compounds

蛋白酪氨酸激酶 (PTKs) 是信号通路中的关键分子，也是药物研发中的重要靶点。细胞中存在两类酪氨酸激酶：受体酪氨酸激酶和非受体酪氨酸激酶。受体酪氨酸激酶包括胰岛素受体及多种生长因子受体，如 EGFR、FGFR、VEGFR、NGFR 等。受体酪氨酸激酶是一类跨膜蛋白，可以被相应配体激活，通过磷酸化自身受体 (自磷酸化) 和下游信号蛋白上的酪氨酸残基，将胞外信号传递到细胞质中。PTKs 的主要作用包括调节机体的多细胞功能。有关生长、分化、粘附、运动和死亡的细胞间信号通常通过酪氨酸激酶传递。在人体中，酪氨酸激酶在许多疾病的发生发展中扮演重要角色，包括糖尿病和癌症。

MCE 收录了 1055 种酪氨酸激酶信号通路相关的产品，可以用于酪氨酸激酶相关药物筛选及疾病研究。

HY-L081

磷酸酶抑制剂库

132 compounds

蛋白磷酸化是一种关键的翻译后修饰，参与了许多细胞进程的调控。磷酸酶和激酶共同调控细胞内蛋白磷酸化的稳态。这种可逆的蛋白磷酸化调节过程对于调控多种细胞内活动至关重要，包括细胞周期、增殖和分化、代谢、细胞与细胞间的相互作用等。

蛋白磷酸酶在结构和作用机制上已经进化成不同的家族，根据底物特异性及功能的不同，可以将磷酸酶分成两大超家族：蛋白丝氨酸/苏氨酸磷酸酶和蛋白酪氨酸磷酸酶。丝氨酸/苏氨酸磷酸酶是一种金属酶，属于两个主要基因家族：磷蛋白磷酸酶（PPP）和金属依赖蛋白磷酸酶（PPM），而蛋白酪氨酸磷酸酶(PTPs) 属于另一类酶，利用磷酸半胱氨酸酶中间体作为其催化作用的一部分。

MCE 收录了 132 种磷酸酶抑制剂，主要靶向蛋白丝氨酸/苏氨酸磷酸酶和蛋白酪氨酸磷酸酶，是磷酸酶药物开发及相关研究的有用工具。

HY-L075

抗肺癌化合物库

1835 compounds

肺癌是癌症中发病率和死亡率最高的一种癌症，是威胁人类健康的一类主要疾病。肺癌主要分为两种：小细胞肺癌和非小细胞肺癌（NSCLC），其中非小细胞肺癌是主要的肺癌类型，约占肺癌发病率的85%。

与所有癌症一样，肺癌可以通过手术、化疗、放射治疗、靶向治疗、免疫治疗或多种治疗方法结合治疗。靶向治疗是肺癌尤其非小细胞肺癌治疗中的重要进展。非小细胞肺癌通常具有广泛的基因特性，可以分为不同的分子亚型，这些亚型存在癌基因依赖性，并且对靶向治疗非常敏感。这些亚型包括表皮生长因子（EGFR）或 BRAF 突变型，EML4 与 ALK 基因融合导致 ALK 的异常表达型及 ROS1 基因与其他基因融合导致 ROS1 异常表达型等。这些都是靶向治疗中的重要靶点。

MCE 提供 1835 个具有明确或潜在抗肺癌活性的化合物，这些化合物靶向肺癌治疗中的关键靶点及信号通路。MCE 抗肺癌化合物库是筛选抗肺癌活性化合物及其他肺癌相关研究的重要工具。

HY-L015

PI3K/Akt/mTOR 化合物库

568 compounds

PI3K/Akt/mTOR 信号通路控制着很多和肿瘤发生发展相关的细胞进程，包括细胞凋亡、转录、翻译、代谢、血管生成和细胞周期进程等。这一信号通路的主要节点都在多数人类肿瘤中被激活。该信号通路激活的机制包括 PI3K 上游的酪氨酸激酶受体被激活，编码 PI3K 催化亚基 p110α 的基因 PIK3CA 突变或扩增，抑癌基因 PTEN 的突变或缺失，Akt1 的突变或扩增等。一旦这条信号通路被激活，信号通过 Akt 激活下游一系列底物，包括参与蛋白合成的 mTOR 靶点。因此，抑制该信号通路是癌症预防和/或治疗的有效途径。最近，一些 mTOR 抑制剂已经被批准用对多种癌症的治疗，还有多种新型的 PI3K/Akt/mTOR 抑制剂处于临床研究中。

MCE 收录了 568 个靶向 PI3K/Akt/mTOR 信号通路的小分子化合物，是抗肿瘤药物开发的有用工具。

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7160

2-Hydroxy-3-methylanthraquinone	Quinones Structural Classification Anthraquinones Source classification Rubiaceae Plants Hedyotis diffusa Willd.	Src Apoptosis
大黄素杂质16 2-Hydroxy-3-methylanthraquinone (compound 1) 从白花蛇耳草的水提取物中分离得到。2-Hydroxy-3-methylanthraquinone 对蛋白酪氨酸激酶 (protein tyrosine kinases) v-src 和 pp60src有抑制作用，诱导 HepG2 癌细胞和凋亡 (apoptosis)。

HY-N2506

Ginsenoside Ra1	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Others
人参皂苷 Ra1 Ginsenoside Ra1 是人参中的成分，抑制缺氧/复氧诱导的蛋白酪氨酸激酶 (PTK) 的激活。

HY-N6732

K-252a 10 篇以上引用文献 SF2370; Antibiotic K 252a; Antibiotic SF 2370	Alkaloids Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Indole Alkaloids	PKC PKA CaMK Trk Receptor Autophagy Antibiotic
K-252a 是一种十字孢碱类似物，是蛋白激酶的抑制剂，对 PKC、PKA、II型钙调素依赖性激酶和磷酸化酶激酶的 IC₅₀ 值分别为470 nM、140 nM、270 nM和1.7 nM。K-252a 是一种有效抑制 NGF 受体 gp140trk 的酪氨酸蛋白激酶 (TRK) 活性，IC₅₀ 为 3 nM。

HY-18963

Lavendustin A RG-14355	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields Cancer	EGFR
薰草菌素 Lavendustin A (RG-14355) 是一种有效，选择性和 ATP 竞争性的表皮生长因子受体 (EGFR) 酪氨酸激酶抑制剂，IC₅₀ 值为 11 nM。Lavendustin A 不会抑制蛋白激酶 A 和 C。Lavendustin A 可以抑制 VEGF 诱导的血管生成。

HY-N4201

β-Hydroxyisovalerylshikonin	Quinones Classification of Application Fields Source classification Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Disease Research Fields Boraginaceae Cancer	EGFR Src
β-羟基异戊酰基紫草素 Beta-hydroxyisovalerylshikonin 是一种从Lithospermum erythrorhizon 中分离出的天然产物，是一种有效的 PTK 抑制剂，对 EGFR 和 v-Src 受体作用的 IC₅₀ 分别为 0.7 μM 和 1 μM。Beta-hydroxyisovalerylshikonin 对多种肿瘤细胞系均有抑制作用，能高效诱导 NCI-H522 和 DMS114 细胞的死亡。

HY-16558

Butein 3 篇文献验证 2’,3,4,4’-tetrahydroxy Chalcone	Structural Classification Chalcones Flavonoids other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	EGFR Autophagy Apoptosis Phosphodiesterase (PDE)
紫铆因 Butein 是一种 cAMP 特异性的 PDE 抑制剂，对 PDE4 的 IC₅₀为 10.4 μM。Butein 是蛋白酪氨酸激酶抑制剂，对 EGFR 和 p60^c-src 的 IC₅₀ 分别为 16 和 65 μM。Butein 通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。Butein 还是一种 SIRT1 激活剂 (STAC)。

Cat. No.	Product Name	Chemical Structure

HY-15463S2

Imatinib-d3 hydrochloride

Imatinib-d₃ (hydrochloride) 是 Imatinib 的氘代物。Imatinib (STI571) 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。Imatinib (STI571) 靠近 ATP 结合位点结合，将其锁定在封闭或自我抑制的构象中，因此半竞争性抑制蛋白质的酶活性。Imatinib 还抑制 SARS-CoV 和 MERS-CoV。

HY-160144S

Lomedeucitinib
Lomedeucitinib (BMS-986322) 通过靶向受体酪氨酸蛋白激酶 (TYK2) 发挥作用。Lomedeucitinib 可用于斑块状银屑病的研究。

Cat. No.	Product Name	Application	Reactivity

HY-P82997

CSK Antibody (YA2742) CSK; tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL	WB, IHC-P	Human, Mouse, Rat

HY-P81458

Brk/PTK6 Antibody (YA1203) PTK6; BRK; protein-tyrosine kinase 6; Breast tumor kinase; tyrosine-protein kinase BRK	IHC-P	Human

HY-P80877

PYK2 Antibody (YA682) PTK2B; FAK2; PYK2; RAFTK; protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P	Human
PYK2 Antibody (YA682) is a non-conjugated and Mouse origined monoclonal antibody about 116 kDa, targeting to PYK2 (4B4). It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P81384

RON Antibody (YA1129) MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; protein-tyrosine kinase 8; p185-Ron; CD136	IHC-P	Human

HY-P80816

Phospho-FAK (Tyr576) Antibody PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; protein phosphatase 1 regulatory subunit 71; PPP1R71; protein-tyrosine kinase 2; p125FAK; pp125FAK	WB	Human, Mouse
Phospho-FAK (Tyr576) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 119 kDa, targeting to Phospho-FAK (Tyr576). It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P81643

VEGFR2 Antibody (YA1388) KDR; FLK1; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1; FLK-1; kinase insert domain receptor; KDR; protein-tyrosine kinase receptor flk-1; CD antigen CD309	FC, ELISA	Human

HY-P80576

BTK Antibody (YA816) BTK; AGMX1; ATK; BPK; tyrosine-protein kinase BTK; Agammaglobulinaemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase	WB, IP	Human
BTK Antibody (YA816) is a non-conjugated and Mouse origined monoclonal antibody about 76 kDa, targeting to BTK (5B12). It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80743

Lck Antibody (YA712) LCK; tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK	WB	Human
Lck Antibody (YA712) is a non-conjugated and Mouse origined monoclonal antibody about 58 kDa, targeting to Lck (3E5). It can be used for WB assays with tag free, in the background of Human.

HY-P82436

Tec Antibody (YA2181) tyrosine-protein kinase Tec	WB, ICC/IF	Human

HY-P83221

MERTK Antibody (YA2966) MERTK; MER; tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK	WB, IHC-P, IP	Human

HY-P81744

Trk A Antibody (YA1489) NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; tyrosine kinase receptor; tyrosine kinase receptor A	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

HY-P83601

ITK Antibody (YA3346) ITK; EMT; LYK; tyrosine-protein kinase ITK/TSK; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase Lyk	WB, IHC-P, FC	Human

HY-P83218

Tyrosine Protein Kinase HCK Antibody (YA2963) HCK; tyrosine-protein kinase HCK; Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck	WB, ICC/IF, IP	Human

HY-P80937

ZAP70 Antibody (YA651) ZAP70; SRK; tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase	WB, IP	Human
ZAP70 Antibody (YA651) is a non-conjugated and Mouse origined monoclonal antibody about 70 kDa, targeting to ZAP70 (4B2). It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80454

Phospho-BTK(Y223) Antibody BTK(Y223); BTK (phospho Y223); p-BTK (phospho Y223); Agammaglobulinaemia tyrosine kinase; AGMX 1; AGMX1; AT; ATK; B cell progenitor kinase; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton’s tyrosine kinase; Btk; BTK_HUMAN; IMD 1; IMD1; MGC126261; MGC126262; OTTHUMP00000063593; PSCTK 1; PSCTK1; tyrosine protein kinase BTK; tyrosine-protein kinase BTK; XLA.	WB, IHC-P, IHC-F, ICC, IF	Human
Phospho-BTK(Y223) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 76 kDa, targeting to Phospho-BTK(Y223). It can be used for WB, IHC-P, IHC-F, ICC, IF assays with tag free, in the background of Human.

HY-P81772

EPHA3 Antibody (YA1517) EPHA3; ETK; ETK1; HEK; TYRO4; Ephrin type-A receptor 3; EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; tyrosine-protein kinase TYRO4; tyrosine-protein kinase receptor ETK1; Eph-like tyrosine kinase 1	FC, ELISA	Human

HY-P83458

ABL2 Antibody (YA3203) ABL2; ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; tyrosine-protein kinase ARG	WB, FC	Human, Mouse, Rat

HY-P81678

MELK Antibody (YA1423) MELK; KIAA0175; Maternal embryonic leucine zipper kinase; hMELK; protein kinase Eg3; pEg3 kinase; protein kinase PK38; hPK38; tyrosine-protein kinase MELK	WB	Human

HY-P80727

JAK2 Antibody (YA330) JAK2; tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2	WB	Human, Mouse
JAK2 Antibody (YA330) is a non-conjugated and Rabbit origined monoclonal antibody about 131 kDa, targeting to JAK2. It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P82883

Phospho-PKC delta (Ser299) Antibody (YA2628) protein kinase C delta type; tyrosine-protein kinase PRKCD; nPKC-delta	WB, IHC-P, IP	Human

HY-P81390

ROR2 Antibody (YA1135) NTRKR; ROR2; tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2	IHC-P	Human

HY-P81198

AXL Antibody Adhesion related kinase; AI323647; Ark; Axl; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming gene; AXL transforming sequence/gene; EC 2.7.10.1; JTK11; Oncogene AXL; Tyro7; tyrosine protein kinase receptor UFO; tyrosine-protein kinase receptor UFO; UFO; UFO_HUMAN.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse(predicted: Rat, Dog, Horse, Rabbit)
AXL Antibody is an unconjugated, approximately 95 kDa, rabbit-derived, anti-AXL polyclonal antibody. AXL Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat, dog, horse, rabbit background without labeling.

HY-P80928

VEGF Receptor 1 Antibody VEGFR-1; VEGF Receptor 1; FLT-1; FLT; FRT; VEGFR1; Fms-like tyrosine kinase 1; tyrosine-protein kinase FRT	WB, IHC-P, IP	Human, Mouse, Rat
VEGF Receptor 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 151 kDa, targeting to VEGF Receptor 1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80829

Phospho-JAK2 (Tyr1007/1008) Antibody JAK2; tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
Phospho-JAK2 (Tyr1007/1008) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 131 kDa, targeting to Phospho-JAK2 (Tyr1007/1008). It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P82721

JAK3 Antibody (YA2466) JAK3; tyrosine-protein kinase JAK3; Janus kinase 3; JAK-3; Leukocyte janus kinase; L-JAK	WB, ICC/IF	Human

HY-P82431

Ephrin Receptor B1 Antibody (YA2176) EPHB1; ELK; EPHT2; HEK6; NET; Ephrin type-B receptor 1; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EK6; hEK6; Neuronally-expressed EPH-related tyrosine kinase; NET; tyrosine-protein kinase receptor EPH-2	WB, IP	Human, Mouse, Rat

HY-P80659

ErbB 3 Antibody ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3	WB	Human
ErbB 3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 148 kDa, targeting to ErbB 3. It can be used for WB assays with tag free, in the background of Human.

HY-P83132

Ephrin Receptor B3 Antibody (YA2877) EPHB3; ETK2; HEK2; TYRO6; Ephrin type-B receptor 3; EPH-like tyrosine kinase 2; EPH-like kinase 2; Embryonic kinase 2; EK2; hEK2; tyrosine-protein kinase TYRO6	WB, ICC/IF, IP, FC	Human, Mouse, Rat

HY-P80747

Lyn Antibody (YA707) LYN; JTK8; tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn	WB	Human
Lyn Antibody (YA707) is a non-conjugated and Mouse origined monoclonal antibody about 59 kDa, targeting to Lyn (1C8). It can be used for WB assays with tag free, in the background of Human.

HY-P83123

DOK1 Antibody (YA2868) DOK1; Docking protein 1; Downstream of tyrosine kinase 1; p62(dok); pp62	WB, ICC/IF	Human, Mouse, Rat

HY-P80726

JAK1 Antibody (YA722) JAK1; JAK1A; JAK1B; tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1	WB, ICC/IF, IP	Human, Rat
JAK1 Antibody (YA722) is a non-conjugated and Mouse origined monoclonal antibody about 133 kDa, targeting to JAK1 (8B8). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Rat.

HY-P80660

ErbB 4 Antibody ERBB4; HER4; Receptor tyrosine-protein kinase erbB-4; Proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; p180erbB4	WB	Human, Rat
ErbB 4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 147 kDa, targeting to ErbB 4. It can be used for WB assays with tag free, in the background of Human, Rat.

HY-P80681

FYN Antibody FYN; tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn	WB	Human, Mouse, Rat
FYN Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 61 kDa, targeting to FYN. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P81255

EphA3 Antibody EK4; End3; Eph receptor A3; EPH-like kinase 4; EPH-like tyrosine kinase 1; EphA3; Ephrin receptor EphA3; Ephrin type-A receptor 3; ETK 1; ETK; ETK1; HEK 4; HEK; Hek4; Human embryo kinase; Mek4; MGC109882; Receptor tyrosine kinase HEK; Tyro 4; Tyro4; tyrosine protein kinase receptor ETK 1; tyrosine-protein kinase TYRO4; AW492086; Cek4; EC 2.7.10.1; EPHA3_HUMAN.	WB; IHC-P; IHC-F; ICC; IF; ELISA;	Mouse, Rat (predicted: Human, Sheep, Cow, Dog, Horse)

HY-P81594

EPHA2 Antibody (YA1339) EPHA2; ECK; Ephrin type-A receptor 2; Epithelial cell kinase; tyrosine-protein kinase receptor ECK	FC, ELISA	Human

HY-P82152

Yes1 Antibody (YA1897) YES1; YES; tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

HY-P83147

Ephrin Receptor B4 Antibody (YA2892) EPHB4; HTK; MYK1; TYRO11; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; tyrosine-protein kinase TYRO11	WB, IHC-P	Human, Mouse, Rat

HY-P80645

DUSP1 Antibody DUSP1; CL100; MKP1; PTPN10; VH1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; protein-tyrosine phosphatase CL100	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
DUSP1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 39 kDa, targeting to DUSP1. It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P81156

phospho-ERK1 + 2 (Thr183/Tyr185) Antibody ERK1 + ERK2 (phospho Thr183/Tyr185); phospho-ERK1/MAPK-1/2(Thr183/Tyr185); ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK1; MAPK2; MGC20180; Microtubule associated protein 2 kinase; Mitogen activated protein kinase 1; Mitogen activated protein kinase 1; Mitogen activated protein kinase 2; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; MK01_MOUSE; p38; p40; p41; p41mapk; p42 MAPK; p42-MAPK; p42MAPK; p42MAPK; p44 ERK1; p44 MAPK; p44ERK1; p44ERK1; p44MAPK; p44MAPK; PRKM 1; PRKM 1; PRKM 2; PRKM 2; PRKM1; PRKM2; protein kinase mitogen activated 1; protein kinase mitogen activated 1; protein kinase mitogen activated 2; protein kinase mitogen activated 2; protein tyrosine kinas.	WB; ELISA; IHC-P; IHC-F; ICC; IF	Human, Mouse(predicted: Rat, Chicken, Dog, Cow, Horse, Rabbit, Guinea Pig)
phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is an unconjugated, approximately 42/44 kDa, rabbit-derived, anti-phospho-ERK1 + 2 (Thr183/Tyr185) polyclonal antibody. phospho-ERK1 + 2 (Thr183/Tyr185) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, and predicted: rat, chicken, dog, cow, horse, rabbit, guinea pig background without labeling.

HY-P80658

HER2 Antibody (YA771) ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
ErbB 2 Antibody (YA771) is a non-conjugated and Mouse origined monoclonal antibody about 138 kDa, targeting to ErbB 2 (1C4). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80648

EGFR Antibody (YA775) EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1	WB, ICC/IF, IP	Human, Monkey
EGFR Antibody (YA775) is a non-conjugated and Mouse origined monoclonal antibody about 134 kDa, targeting to EGFR (6H11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Monkey.

HY-P80808

Phospho-EGFR (Tyr1068) Antibody EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1	WB, IHC-F, IHC-P, ICC/IF	Human
Phospho-EGFR (Tyr1068) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Phospho-EGFR (Tyr1068). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P80809

Phospho-EGFR (Tyr1092) Antibody EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1	WB, IHC-P	Human, Mouse, Rat
Phospho-EGFR (Tyr1092) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Phospho-EGFR (Tyr1092). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80810

Phospho-EGFR (Tyr1173) Antibody EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
Phospho-EGFR (Tyr1173) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Phospho-EGFR (Tyr1173). It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

HY-P82911

Phospho-Src (Tyr530) Antibody (YA2656) SRC; SRC1; Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-src; p60-Src	WB, IP	Rat

HY-P80803

Phospho-c-Met (Tyr1349) Antibody MET; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; tyrosine-protein kinase Met	WB, IP	Human
Phospho-c-Met (Tyr1349) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 156 kDa, targeting to Phospho-c-Met (Tyr1349). It can be used for WB,IP assays with tag free, in the background of Human.

HY-P83523

General Transcription Factor II I Antibody (YA3268) GTF2I; BAP135; WBSCR6; General transcription factor II-I; GTFII-I; TFII-I; Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; SPIN; Williams-Beuren syndrome chromosomal region	WB, IHC-F, IHC-P, ICC/IF	Human

HY-P80619

c-Kit Antibody KIT; SCFR; Mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
c-Kit Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 110 kDa, targeting to c-Kit. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Rat, Monkey.

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Species:	Human (163) Rhesus Macaque (11) Rat (18) Mouse (39) Cynomolgus (5) Rabbit (1) Pig (1) Canine (2)
Tag:	His (139) SUMO (1) Tag Free (25) Avi (18) Myc (2) GST (47) Flag (11) Fc (48) B2M (1)
Source:	HEK293 (135) Sf9 insect cells (4) CHO (1) Sf9 insect cells (72) P. pastoris (6) E. coli (21)


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